What Is VDR?

VDR is a gene which encodes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene known as the rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by the two components, and is affected by chromosomal positions and binding preferences for certain hormones. Studies of microarrays in human cells reveal that more than 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) can be an archive of information and documents that are relevant to legal transactions, business, or processes. Access to the data, downloading, or printing are not permitted. It makes use of a central computer and an extranet which is a restricted access Internet connection, allowing users to login at specific times.

Companies and investment banks that are involved in mergers and acquisitions are among the most frequent users of VDRs. VDR. They need an encrypted platform to share information with potential buyers or investors in a way that is transparent, and due diligence may require large amounts of information. Life science firms also use VDRs for everything from clinical trial data to HIPAA documentation for compliance.


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